SMTP authentication has failed when sending test email

SBS2011 with Exchange 2010 version 14.03.0174.001
Domain controller, DHCP, DNS, Vipre Business, GFI MailEssentials
Setup exchange relay Hub Transport>Receive connectors>Specify FQDN server.domain.local
Network tab > 192.168.11.3 port 25
Receive from remote servers 0.0.0.0-255.255.255.255
Authentication Transport layer security (TLS)
Permission Groups > Anonymous users and Exchange users
Restarted Exchange IS service
Acronis email notification settings
Email address added
SMTP server: mail.domain.com
Port 25
Username: administrator@domain.com
Password: administrator password
No additional parameters set
Test send email get following error log.
Code: 21,954,592(0x14F0020)
LineInfo: 0xDA7E497CF4160E20;

Module: disk_bundle_vs
Message: Failed to send the message from '' to 'tech@seanspcpower.com' (SMTP 'mail.milleen.com:25').

Code: 21,954,582(0x14F0016)
LineInfo: 0xDA7E497CF4160E04;

Module: disk_bundle_vs
Message: SMTP authentication has failed.

Acronis Knowledge Base: http://kb.acronis.com/errorcode/

Event code: 0x014F0020+0x014F0016

Please assist.