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Acronis17 on win 10 64 bit

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John, welcome to these User Forums.

I can think of no reason why ATI 2017 will not recognise your 4TB drive if this is recognised by your Windows 10 OS.

The only real question mark is to ask how is the 4TB drive formatted as there are some restrictions for ATI in this area.  In particular exFAT formatted drives are not supported.

See the ATI 2017 User Guide: 

Supported file systems

  • FAT16/32
  • NTFS
  • Ext2/Ext3/Ext4 *
  • ReiserFS *

    Note: ReiserFS partitions and disks cannot be backed up to Acronis Cloud.

  • Linux SWAP *

* The Ext2/Ext3/Ext4, ReiserFS, and Linux SWAP file systems are supported only for disk or partition backup/recovery operations. You cannot use Acronis True Image 2017 for file-level operations with these file systems (file backup, recovery, search, as well as image mounting and file recovering from images). You also cannot perform backups to disks or partitions with these file systems.