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Bootable usb not recognized

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Lou, welcome to these public User Forums.

What type of Acronis bootable rescue media are you using?

For the rescue media, there are 3 different versions available:
Simple:  created based on your Windows Recovery Environment for WinPE media.
Advanced: created based on Windows ADK (or AIK for earlier OS versions) - WinPE media.
Advanced: created based on a small Linux distro OS (BusyBox).

I would recommend creating the Windows PE version of the Acronis Rescue Media as described in the KB documents below.  I would expect this to be more reliable.

KB 60820: Acronis True Image 2018: how to create bootable media

KB 60091: Acronis True Image 2018: how Simple bootable media creation mode works

Next, how does your Windows 10 OS boot from the BIOS and are you booting the rescue media in the same BIOS mode.

See KB 59877: Acronis True Image: how to distinguish between UEFI and Legacy BIOS boot modes of Acronis Bootable Media which will also help you to check how your Windows boots.

Also, does it boot on other machines (can you test)?  Some computers have secure-boot enabled by default which will prevent 3rd party bootloaders from being allowed to run.  If it boots on other machines, but not the one it was built on, secure boot is likely the issue.  You may have to refer to your bios manual for more information about disabling it or turning it off.