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cloning windows 10 home to new Pcie nvme kingston 250 gb

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John, welcome to these public User Forums.

Sorry but more information is needed here?

What exactly are you cloning from / to and how are you doing the clone?

What version of Acronis True Image are you using?  Is this a free version supplied with the Kingston SSD or a full licensed version?

NVMe type drives normally require the PC boots using UEFI / GPT mode.  The original Source disk for a clone should be removed before attempting to boot from the Target cloned drive.

A full disk backup should be created of the Source drive before attempting any clone operation - this is your safety net in the event of mistakes or issues arising.

Please see KB 56634: Acronis True Image: how to clone a disk - and review the step by step guide given there.

Note: the first section of the above KB document directs laptop users to KB 2931: How to clone a laptop hard drive - and has the following paragraph:

It is recommended to put the new drive in the laptop first, and connect the old drive via USB. Otherwise you will may not be able to boot from the new cloned drive, as Acronis True Image will apply a bootability fix to the new disk and adjust the boot settings of the target drive to boot from USB. If the new disk is inside the laptop, the boot settings will be automatically adjusted to boot from internal disk. As such, hard disk bays cannot be used for target disks. For example, if you have a target hard disk (i.e. the new disk to which you clone, and from which you intend to boot the machine) in a bay, and not physically inside the laptop, the target hard disk will be unbootable after the cloning.

Acronis True Image 2019 and 2020: Active Cloning in Windows | Knowledge Base

KB 65508: Acronis True Image 2021: how to create bootable media

KB 59877: Acronis True Image: how to distinguish between UEFI and Legacy BIOS boot modes of Acronis Bootable Media