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Cloned disk not loading from USB hard drive

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Using TI 2021 the program backs up my primary drive just fine to my USB connected HDD.  When I pull my primary hard drive to test the backup through USB I get the blue screen inaccessable boot disk error.  If I connect the backed up drive directly in my case it works like a champ.  Something is causing the backup not to work from my USB external case.  My bios cannot disable secure boot.  Thoughts?

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Frank, welcome to these public User Forums.

The limitations on booting Windows from any external USB drive is imposed by Microsoft who do not allow this because of licensing issues!