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"Destination disk not accessible"

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I'm trying to backup selected directories from my "C:" and "E:" disks, destination is an external USB-disk with 4TB capacity. I want to establish a weekly incremental backup scheme.
The first complete backup went through perfectly, but every subsequent backup, both automatically and manually started, cancels after some time with the message that the destination disk is not accessible. It *is* accessible, though.

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Herbert, welcome to these public User Forums.

The log for your backup task may hold some clues to what is happening here?

Download a copy of the MVP Assistant log viewer tool and use this to look at the logs to see if they show any issues during the operation process?

The latest version of the new log viewer tool is at the link below. 
MVP Assistant update for Acronis Cyber Protect Home Office (Version 1.1.6.0)

If you have Disks & Partitions backups created on ATI 2020 or later using .tibx files, then look in the Backup Worker logs.

If you have Files & Folders backups using .tib files (or Disk backups from earlier versions using .tib files) or using Cloning then look in the Demon logs.

Other logs are shown by the MVP Assistant under the 'Active Logs' heading of the Log Viewer page of the Assistant.

The Schedule2 log contains information related to scheduled task but is one of the more difficult logs to read / work through.

The log files should be zipped to preserve their original file names if sharing in the forums and would need to be less than 3MB in size, otherwise you would need to share the zip file via a Cloud share service such as OneDrive, Dropbox etc.

The other area to check is your USB Power settings, in particular whether you have USB Selective Suspend enabled which could allow the 4TB drive to go to sleep while the task is active.

Hello Steve,

thank you for your answer, and appologies for not answering for a long time.

I still have no idea why the harddisk doesn't work. I tried a few things, but switched the hd to another laptop, where it works flawlessly. The difference might be that the laptop where I tried it first is running Windows 7, while the other laptop runs Windows 10.

I think I'll try again with the other laptop.